Description
| Product Name: | Mouse CD18 monoclonal antibody (FITC) |
| Product Code: | AGIM0500 |
| Size: | 100 µL |
| Reactivity: | Mouse |
| Clone: | M18/2 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG2a |
| Host Species: | Rat |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P05107 |
| Background: | CD18 is a 95 kD protein, also known as integrin ??2 subunit. It is expressed on all leukocytes. CD18, in association with integrin ?± chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and ?±X??2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion. |
| UniProt Protein Function: | ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1). |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Cell surface; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex; vesicle; lipid raft Molecular Function:protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity; glycoprotein binding; protein kinase binding Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cellular extravasation; cell-cell signaling; inflammatory response; cell adhesion; toll-like receptor 4 signaling pathway; regulation of peptidyl-tyrosine phosphorylation; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; innate immune response; endothelial cell migration; blood coagulation; leukocyte migration Disease: Leukocyte Adhesion Deficiency, Type I |
| NCBI Summary: | This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P05107 |
| NCBI GenInfo Identifier: | 124056465 |
| NCBI Gene ID: | 3689 |
| NCBI Accession: | P05107.2 |
| UniProt Secondary Accession: | P05107,Q16418, Q53HS5, Q9UD72, B3KTS8, D3DSM1, |
| UniProt Related Accession: | P05107 |
| Molecular Weight: | 769 |
| NCBI Full Name: | Integrin beta-2 |
| NCBI Synonym Full Names: | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
| NCBI Official Symbol: | ITGB2Â Â |
| NCBI Official Synonym Symbols: | LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1Â Â |
| NCBI Protein Information: | integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor) |
| UniProt Protein Name: | Integrin beta-2 |
| UniProt Synonym Protein Names: | Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18 |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGB2Â Â |
| UniProt Entry Name: | ITB2_HUMAN |
![FITC Anti-Mouse CD18 Antibody [M18/2] (AGEL1418)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/237510/617963/fitc-anti-mouse-cd18-antibody-m182-agel1418__17400.1732237428.jpg?c=2 "FITC Anti-Mouse CD18 Antibody [M18/2] (AGEL1418)")
![FITC Anti-Mouse CD18 Antibody [M18/2] (AGEL1420)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/237512/618362/fitc-anti-mouse-cd18-antibody-m182-agel1420__48565.1732238731.jpg?c=2 "FITC Anti-Mouse CD18 Antibody [M18/2] (AGEL1420)")
