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GenieFluor 488 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0736)

Datasheet MSDS
SKU AGEL0736
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
$149 - $314

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Description

system_update_altDatasheetsystem_update_altMSDS

GenieFluor 488 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody (AF488 Conjugated) - CY34.1 (AGEL0736) is a specialized tool for researchers studying CD22, a cell surface protein known for its role in B cell signaling and development. This monoclonal antibody, conjugated with AF488 for fluorescence applications, is specifically designed for use in flow cytometry, immunofluorescence, and other fluorescence-based assays. By binding to CD22, this antibody allows for the visualization and analysis of CD22 expression in mouse samples, facilitating investigations into immune responses, B cell function, and antibody-mediated immunity.

CD22 is a crucial regulator of B cell activation and function, serving as a modulator of B cell receptor signaling and promoting immune tolerance. Studies involving CD22 have significant implications in understanding autoimmune diseases, B cell malignancies, and immune dysregulation. This monoclonal antibody provides researchers with a precise tool to investigate the expression and localization of CD22 in different cellular contexts, enabling a deeper exploration of the mechanisms underlying B cell responses and potential therapeutic targets in immunological disorders.

Product Title:GenieFluor 488 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0736
Size:25µg, 100µg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 488 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.
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