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PE/Cyanine5 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0732)

Datasheet MSDS
SKU AGEL0732
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
$149 - $363

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Description

system_update_altDatasheetsystem_update_altMSDS

PE/Cyanine5 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody (PE/Cyanine5 Conjugated, CY34.1, AGEL0732) from Assay Genie is a highly specific antibody designed for research involving the CD22 cell surface molecule. CD22, also known as Siglec-2, is a B cell-specific membrane protein involved in regulating B cell activation and signaling.This monoclonal antibody is conjugated with PE/Cyanine5 for easy detection and analysis in flow cytometry applications. It is ideal for identifying and studying CD22 expression in mouse samples, making it a valuable tool for immunology and B cell research.

The specificity and sensitivity of this antibody make it a reliable choice for investigating the role of CD22 in various cellular processes, including B cell development, activation, and immune response modulation. Its use can contribute to a better understanding of B cell function and the development of targeted therapies for B cell-related disorders.Overall, the Mouse CD22 Monoclonal Antibody (PE/Cyanine5 Conjugated, CY34.1, AGEL0732) provides researchers with a powerful tool to advance their studies in immunology, B cell biology, and related fields.

Product Title:PE/Cyanine5 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0732
Size:25µg, 100µg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.
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