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APC Anti-Mouse CD28 Antibody [37.51] (AGEL0768)

Datasheet MSDS
SKU AGEL0768
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Hamster
Isotype IgG2a,k
Clone 37.51
Conjugation APC
€98 - €275

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse CD28 Antibody [37.51]

The Mouse CD28 Monoclonal Antibody (APC-conjugated) AGEL0768 is a crucial tool for research involving the CD28 protein, a costimulatory molecule essential for T cell activation and proliferation. This antibody, generated using a monoclonal approach, shows high specificity and sensitivity towards mouse samples, making it an ideal choice for flow cytometry applications. By binding specifically to CD28, this antibody enables precise detection and analysis of CD28 expression on various immune cells, facilitating investigations in immunology and vaccine development.CD28 is a co-stimulatory receptor expressed on T cells that plays a pivotal role in the regulation of immune responses by providing signals for T cell activation and effector functions.

Understanding the function and expression pattern of CD28 is crucial for unraveling the mechanisms underlying T cell activation and tolerance, making this antibody an invaluable resource for studies in autoimmune diseases, transplantation, infectious diseases, and immunotherapy research. By targeting CD28, researchers can explore novel strategies to modulate immune responses and design innovative immunotherapies for various pathological conditions.

Product Title:APC Anti-Mouse CD28 Antibody [37.51]
SKU:AGEL0768
Size:25µg, 100µg
Clone No:37.51
Synonyms:T-cell-specific surface glycoprotein CD28;Cd28;CD28;
Host Species:Syrian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P31041
Gene ID:12487
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD28 is a 44 kD glycoprotein, also known as Tp44 or T44. It is a member of the Ig superfamily, expressed on thymocytes, most peripheral T cells, and NK cells. In association with CD80 (B7-1) and CD86 (B7-2), CD28 acts as the second signal for T and NK cell activation and proliferation. The 37.51 antibody has been reported to augment in vitro T cell proliferation and cytokine production, and promote CTL development.
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