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Mouse CD289/TLR9 Recombinant Protein (N-His)
Key Features

Mouse CD289/TLR9 Recombinant Protein (N-His) (GXRP10212)

SKU GXRP10212
Product Type Recombinant Protein
Species Mouse
Expression System E. coli
Tag N-His
$458 - $2,412

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Description

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Mouse CD289/TLR9 Recombinant Protein (N-His)

Mouse CD289/TLR9 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu26-Asp421, with an N-terminal His tag. Predicted molecular weight: 47.03 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Toll-like receptor 9 is a ~116 kDa protein. Key component of innate and adaptive immunity. For research use only.

TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome.

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