Anti-Mouse CD3 Antibody (AGIM0256)

Mouse CD3 monoclonal antibody (AGIM0256)

SKU:

AGIM0256

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Mouse

Host Species:

Hamster

Isotype:

IgG1, k

Clone:

DaA3

Conjugation:

Unconjugated

Applications:

Description

Description

Datasheet

Isotype:	IgG1, k
Host Species:	Hamster
Storage:	Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:	P04234

UniProt Protein Function:	CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 11q23 Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex Molecular Function:transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection Disease: Immunodeficiency 19
NCBI Summary:	The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
UniProt Code:	P04234
NCBI GenInfo Identifier:	115985
NCBI Gene ID:	915
NCBI Accession:	P04234.1
UniProt Secondary Accession:	P04234,A8MVP6,
UniProt Related Accession:	P04234
Molecular Weight:	171
NCBI Full Name:	T-cell surface glycoprotein CD3 delta chain
NCBI Synonym Full Names:	CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol:	CD3D
NCBI Official Synonym Symbols:	T3D; IMD19; CD3-DELTA
NCBI Protein Information:	T-cell surface glycoprotein CD3 delta chain; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex)
UniProt Protein Name:	T-cell surface glycoprotein CD3 delta chain
UniProt Synonym Protein Names:	T-cell receptor T3 delta chain; CD_antigen: CD3d
Protein Family:	CD302 antigen
UniProt Gene Name:	CD3D
UniProt Entry Name:	CD3D_HUMAN