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GenieFluor 647 Anti-Mouse CD40 Antibody [FGK4.5/FGK45] (AGEL0790)

Datasheet MSDS
SKU AGEL0790
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone FGK4.5/FGK45
Conjugation AF 647
$132 - $314

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Description

system_update_altDatasheetsystem_update_altMSDS

GenieFluor 647 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]

The Mouse CD40 Monoclonal Antibody (AF647 Conjugated, FGK4.5, FGK45) (AGEL0790) offered by Assay Genie is a specialized tool for researchers investigating the CD40 protein in mouse models. This monoclonal antibody, conjugated with AF647 for fluorescent detection, specifically targets CD40, a crucial cell surface receptor involved in immune response regulation and activation.CD40 is a key player in the adaptive immune system, functioning as a co-stimulatory molecule in interactions between antigen-presenting cells and T cells. By binding to CD40, this antibody facilitates the visualization and analysis of CD40 protein expression in various experimental settings, making it a valuable asset in immunology and related research areas.

Utilizing this antibody in conjunction with fluorescence-based techniques allows for precise localization and quantification of CD40 levels in mouse tissues or cell cultures. Its specificity and sensitivity ensure reliable results in applications such as immunofluorescence microscopy, flow cytometry, and other fluorescence-based assays. Researchers exploring immune signaling pathways, vaccine development, or autoimmune disorders will benefit from the performance and versatility of this AF647-conjugated CD40 monoclonal antibody from Assay Genie.

Product Title:GenieFluor 647 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]
SKU:AGEL0790
Size:25µg, 100µg
Clone No:FGK4.5/FGK45
Synonyms:Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27512
Gene ID:21939
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.
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