Purified Anti-Mouse CD40 Antibody [FGK4.5/FGK45] (AGEL0140)
- SKU:
- AGEL0140
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- IgG2a
- Clone:
- FGK4.5/FGK45
- Conjugation:
- Unconjugated
- Applications:
- FC
Frequently bought together:
Description
Product Title: | Purified Anti-Mouse CD40 Antibody [FGK4.5/FGK45] |
SKU: | AGEL0140 |
Size: | 25µg, 100µg |
Clone No: | FGK4.5/FGK45 |
Synonyms: | Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5; |
Host Species: | Rat |
Reactivity: | Mouse |
Application: | FCM |
Isotype: | Rat IgG2a, κ |
Isotype Control: | Purified Rat IgG2a, κ Isotype Control[2A3] |
Form: | Liquid |
Conjugation: | Unconjugated |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Swissprot: | P27512 |
Gene ID: | 21939 |
Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
Stability & Storage: | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Background: | CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation. |