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Biotin Anti-Mouse CD49b Antibody [DX5] (AGEL0436)

Datasheet MSDS
SKU AGEL0436
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgM
Clone DX5
Conjugation Biotin
Applications FC
€69 - €200

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Description

system_update_altDatasheetsystem_update_altMSDS

Biotin Anti-Mouse CD49b Antibody [DX5]

The Mouse CD49b Monoclonal Antibody (Biotin-conjugated, DX5, AGEL0436) is a valuable tool for researchers studying immune cell populations and cell adhesion processes in mice. This antibody, specifically targeting CD49b, a cell surface integrin involved in cell migration and adhesion, is monoclonal and biotin-conjugated for versatile detection and analysis applications.CD49b, also known as DX5, is a marker for natural killer (NK) cells and a subset of T cells in mice, making it a crucial molecule in immunology research. The monoclonal antibody, produced for high specificity and sensitivity, facilitates the identification and isolation of CD49b-expressing cells in various mouse tissues and models.

Its biotin conjugation allows for easy detection using standard techniques like flow cytometry, immunohistochemistry, and Western blotting.By utilizing the Mouse CD49b Monoclonal Antibody (Biotin-conjugated, DX5, AGEL0436), researchers can gain valuable insights into the role of CD49b in immune responses, inflammation, and immune cell interactions in mouse models. This antibody is a reliable tool for a wide range of studies in immunology, cancer research, and autoimmune disorders that require precise detection and characterization of CD49b-expressing cells and tissues in mouse samples.

Product Title:Biotin Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL0436
Size:25µg, 100µg
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:Biotin Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.
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