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APC Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL0712)

Datasheet MSDS
SKU AGEL0712
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone YN1/1.7.4
Conjugation APC
€90 - €213

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse CD54 Antibody [YN1/1.7.4]

The Mouse CD54 Monoclonal Antibody (APC Conjugated) (YN1/1.7.4) is a powerful tool for research involving CD54, a key cell adhesion molecule involved in immune responses and inflammation. This monoclonal antibody, conjugated with APC for enhanced detection capabilities, is specifically designed for use in flow cytometry and immunofluorescence applications. It targets the CD54 protein, allowing for precise identification and analysis of CD54 expression in various cell types, making it an excellent choice for studies in immunology, inflammation, and infectious diseases.CD54, also known as Intercellular Adhesion Molecule-1 (ICAM-1), plays a crucial role in mediating adhesion and interactions between immune cells and endothelial cells during inflammatory responses.

Understanding the regulation and function of CD54 is essential for unraveling the complexities of immune cell communication and inflammatory processes. Research involving CD54 has implications for a wide range of conditions, including autoimmune diseases, viral infections, and inflammatory disorders. By utilizing the Mouse CD54 Monoclonal Antibody (APC Conjugated), researchers can elucidate the roles of CD54 in immune cell interactions and advance our knowledge of immune system dynamics in health and disease.

Product Title:APC Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:AGEL0712
Size:25µg, 100µg
Clone No:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P13597
Gene ID:15894
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
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