Description
Mouse CD83 Recombinant Protein (N-GST & C-His)
Mouse CD83 Recombinant Protein (N-GST & C-His) is a recombinant protein expressed in E. coli, spanning Met22-Cys120, with an N-terminal GST tag and a C-terminal His tag. Predicted molecular weight: 38.89 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. CD83 antigen is a ~21 kDa protein. Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. For research use only.
Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8. Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII. In addition, acts as an important modulator of protective responses against acute infections. 1. von Rohrscheidt, J. et al. (2016) The Journal of experimental medicine 213, 1685-94. PMID: 27503071 2. Liu, H. et al. (2016) The Journal of experimental medicine 213, 1695-703. PMID: 27503069 3. Wild, AB. et al. (2019) JCI insight 4. PMID: 31527313
| Product Name: | Mouse CD83 Recombinant Protein (N-GST & C-His) |
| SKU: | GXRP06468 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | CD83, hCD83, CD83 antigen, B-cell activation protein, Cell surface protein HB15 |
| Tag: | N-GST & C-His |
| Expression Host: | E. coli |
| Protein Length: | Met22-Cys120 |
| Calculated MW: | 38.89 kDa |
| UniProt: | O88324 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
