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GenieFluor 647 Anti-Mouse CD86 Antibody [GL-1] (AGEL0560)

Datasheet MSDS
SKU AGEL0560
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone GL-1
Conjugation AF 647
€100 - €238

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Description

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GenieFluor 647 Anti-Mouse CD86 Antibody [GL-1]

The Mouse CD86 Monoclonal Antibody (AF647 Conjugated) (GL-1) is a cutting-edge tool for researchers studying immune responses and cell communication. This antibody is specifically designed to target CD86, a crucial cell surface molecule involved in T cell activation and regulation.By utilizing the AF647 conjugated GL-1 monoclonal antibody, researchers can accurately detect and analyze CD86 expression in mouse samples, providing valuable insights into immune system function. This antibody is highly reactive and has been extensively validated for use in various experimental applications, including flow cytometry and immunofluorescence.CD86 is a key co-stimulatory molecule that plays a pivotal role in mediating immune responses and controlling T cell activation.

Understanding the expression and function of CD86 is essential for unraveling the complexities of the immune system and developing targeted therapies for conditions such as autoimmune diseases, infections, and cancer.Researchers in the fields of immunology, oncology, and vaccine development will benefit from the precision and reliability of the Mouse CD86 Monoclonal Antibody (AF647 Conjugated) (GL-1), making it an indispensable tool for advancing scientific discoveries in immune regulation and disease treatment.

Product Title:GenieFluor 647 Anti-Mouse CD86 Antibody [GL-1]
SKU:AGEL0560
Size:25µg, 100µg
Clone No:GL-1
Synonyms:T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P42082
Gene ID:12524
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.
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