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GenieFluor 488 Anti-Mouse CD8a Antibody [53-6.7] (AGEL1344)

Datasheet MSDS
SKU AGEL1344
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone 53-7.6
Conjugation AF 488
€38 - €100

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Description

system_update_altDatasheetsystem_update_altMSDS

GenieFluor 488 Anti-Mouse CD8a Antibody [53-6.7]

The Mouse CD8a Monoclonal Antibody (AF488 Conjugated) 53-7.6 (AGEL1344) is a specialized antibody designed for researchers working with mouse models and investigating the CD8a protein. CD8a is a cell surface glycoprotein expressed on cytotoxic T cells and plays a crucial role in immune response regulation, particularly in cytotoxic T cell activation and function.This monoclonal antibody, conjugated with AF488 for fluorescence detection, is specifically tailored for the identification and analysis of CD8a in mouse samples. Its high specificity and sensitivity make it an excellent tool for flow cytometry and immunofluorescence applications, allowing for precise visualization and quantification of CD8a-expressing cells in various tissues and experimental conditions.

By targeting CD8a, researchers can gain insights into T cell-mediated immune responses, such as antigen recognition and cytotoxic activity. This antibody is a valuable resource for studies focusing on immunology, infectious diseases, cancer immunotherapy, and autoimmune disorders in mouse models. Its reliable performance and accurate detection make it an essential component of cutting-edge research in the field of immunology.

Product Title:GenieFluor 488 Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL1344
Size:25µg, 100µg
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
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