Description
Mouse CISH Recombinant Protein (N-His)
Mouse CISH Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu61-Asp174, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Cytokine-inducible SH2-containing protein is a ~28 kDa protein. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. For research use only.
CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
| Product Name: | Mouse CISH Recombinant Protein (N-His) |
| SKU: | GXRP14037 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | CIS, CIS-1, Cis, Cish, Cytokine-inducible SH2-containing protein, SOCS, Suppressor of cytokine signaling |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Leu61-Asp174 |
| UniProt: | Q62225 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
