Description
Mouse DYRK1A Recombinant Protein (N-His)
Mouse DYRK1A Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met156-Lys480, with an N-terminal His tag. Predicted molecular weight: 39.76 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Dual specificity tyrosine-phosphorylation-regulated kinase 1A is a ~85 kDa protein. Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. For research use only.
Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A.
| Product Name: | Mouse DYRK1A Recombinant Protein (N-His) |
| SKU: | GXRP10464 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dyrk, Dyrk1a, EC:2.7.11.23, EC:2.7.12.1, MNBH, MP86, Protein kinase minibrain homolog |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met156-Lys480 |
| Calculated MW: | 39.76 kDa |
| UniProt: | Q61214 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
