Description
Mouse HSD11B1 Recombinant Protein (N-His)
Mouse HSD11B1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu25-Asn292, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. 11-beta-hydroxysteroid dehydrogenase 1 is a ~32 kDa protein. Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone in the presence of NADP(H). For research use only.
Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes. Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids. It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates. Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others.
| Product Name: | Mouse HSD11B1 Recombinant Protein (N-His) |
| SKU: | GXRP13936 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | 11-DH, 11-beta-HSD1, 11-beta-HSD1A/MCR, 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase, 11beta-HSD1A, 7-oxosteroid reductase, Corticosteroid 11-beta-dehydrogenase isozyme 1, EC:1.1.1.146, EC:1.1.1.201, Hsd11, Hsd11b1, liver-type 11-beta-HSD |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu25-Asn292 |
| UniProt: | P50172 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
