Mouse IL1RA Recombinant Protein (RPPB0472)
- SKU:
- RPPB0472
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P25085
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL1RA Recombinant Protein |
| Product Code: | RPPB0472 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | IL1RA |
| Synonyms: | IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, F630041P17Rik. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IL1RA solution (1 mg/ml) contains 10% Glycerol, 20mM Tris-HCl buffer (pH 8.0) and 0.1M NaCl |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than�95.0%�as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMRPSGK RPCKMQAFRI WDTNQKTFYL RNNQLIAGYLQGPNIKLEEK IDMVPIDLHS VFLGIHGGKL CLSCAKSGDD IKLQLEEVNI TDLSKNKEEDKRFTFIRSEK GPTTSFESAA CPGWFLCTTL EADRPVSLTN TPEEPLIVTK FYFQEDQ |
| Biological Activity: | Measured by the ability to inhibit proliferation using D10.G4.1 mouse helper T cells. ED50 for this effect is ? 60 ng/ml with Mouse IL-1 alpha. |
Interleukin-1 ra is a member of the interleukin 1 cytokine family. IL1RAinhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. IL1RAand five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.
IL1RA Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (27-178 aa) and having a molecular mass of 20kDa.IL1RA is fused to a 25 amino acid His tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Vesicle; Cytokine; Secreted, signal peptide Cellular Component: extracellular space; cell; cytoplasm; extracellular region; vesicle Molecular Function:interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity Biological Process: positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; cytokine and chemokine mediated signaling pathway; response to glucocorticoid stimulus; sensory perception of pain; fever; memory; insulin secretion; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; lipid metabolic process; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis |
| UniProt Code: | P25085 |
| NCBI GenInfo Identifier: | 124313 |
| NCBI Gene ID: | 16181 |
| NCBI Accession: | P25085.1 |
| UniProt Secondary Accession: | P25085,O70207, |
| UniProt Related Accession: | P25085 |
| Molecular Weight: | 17,996 Da |
| NCBI Full Name: | Interleukin-1 receptor antagonist protein |
| NCBI Synonym Full Names: | interleukin 1 receptor antagonist |
| NCBI Official Symbol: | Il1rn�� |
| NCBI Official Synonym Symbols: | IL-1ra; F630041P17Rik�� |
| NCBI Protein Information: | interleukin-1 receptor antagonist protein; IRAP; IL-1RN; IL1 inhibitor |
| UniProt Protein Name: | Interleukin-1 receptor antagonist protein |
| UniProt Synonym Protein Names: | IL1 inhibitor |
| Protein Family: | Interleukin-1 receptor antagonist protein |
| UniProt Gene Name: | Il1rn�� |
| UniProt Entry Name: | IL1RA_MOUSE |
