Description
Mouse IL36A/IL-1F6 Recombinant Protein (N-His)
Mouse IL36A/IL-1F6 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-His160, with an N-terminal His tag. Predicted molecular weight: 20.18 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Interleukin-36 alpha (IL36A/IL-1F6) is a ~18 kDa protein. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. For research use only.
Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II.
| Product Name: | Mouse IL36A/IL-1F6 Recombinant Protein (N-His) |
| SKU: | GXRP05798 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | Interleukin-36 alpha, Il1h1, Il36a, Il1e, Interleukin-1 family member 6, Il1f6, IL-1 epsilon, IL-1H1, Fil1e, IL-1F6, Interleukin-1 homolog 1, Interleukin-1 epsilon, FIL1 epsilon, IL-36α, IL36α |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-His160 |
| Calculated MW: | 20.18 kDa |
| UniProt: | Q9JLA2 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
