Description
Mouse IL4I1 Recombinant Protein (N-His)
Mouse IL4I1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Asp40-Gly507, with an N-terminal His tag. Predicted molecular weight: 54.51 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. L-amino-acid oxidase (IL4I1) is a ~70 kDa protein. Secreted L-amino-acid oxidase that acts as a key immunoregulator. For research use only.
Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer.
| Product Name: | Mouse IL4I1 Recombinant Protein (N-His) |
| SKU: | GXRP05849 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | IL4-induced protein 1, Interleukin-4-induced protein 1, Fig1, mIL4I1, Protein Fig-1, mFIG1, Il4i1, LAO, LAAO, L-amino-acid oxidase |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Asp40-Gly507 |
| Calculated MW: | 54.51 kDa |
| UniProt: | O09046 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
