Mouse KLK8 Recombinant Protein (RPPB1869)
- SKU:
- RPPB1869
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q61955
- Research Area:
- Enzymes
Description
| Product Name: | Mouse KLK8 Recombinant Protein |
| Product Code: | RPPB1869 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | KLK8 |
| Synonyms: | Ovasin, PRSS19, TADG14, NRPN, NP, Kallikrein 8(Neuropsin/Ovasin) 2 EC 3.4.21.118, Kallikrein-8, Neuropsin, EC 3.4.21 61,HNP, HK8 |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | KLK8 protein 0.5mg/ml is supplied in PBS, pH-7.4, and 10%Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QGSKILEGRE CIPHSQPWQA ALFQGERLIC GGVLVGDRWV LTAAHCKKQK YSVRLGDHSL QSRDQPEQEI QVAQSIQHPC YNNSNPEDHS HDIMLIRLQN SANLGDKVKP VQLANLCPKV GQKCIISGWG TVTSPQENFP NTLNCAEVKI YSQNKCERAY PGKITEGMVC AGSSNGADTC QGDSGGPLVC DGMLQGITSW GSDPCGKPEK PGVYTKICRY TTWIKKTMDN RDLEHHHHHH |
Kallikrein-8is a serine protease which degrades various proteins such as casein,fibrinogen, kininogen, fibronectin and collagen type IV. Kallikrein-8 takespart in the formation and maturation of orphan and small synaptic boutons inthe Schaffer-collateral pathway, regulates Schaffer-collateral long-termpotentiation in the hippocampus and is essential for memory acquisition andsynaptic plasticity. Kallikrein-8 participates in the secondary phase ofpathogenesis following spinal cord injury and also takes part in skindesquamation and keratinocyte proliferation.
KLK8 Mouse Recombinant produced in Sf9 is a single, glycosylated polypeptide chain containing 240 amino acids (29-260) and having a molecular mass of 26.5kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). The KLK8 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KLK8: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Belongs to the peptidase S1 family. Kallikrein subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; EC 3.4.21.118; Protease; Secreted; Cell development/differentiationCellular Component: extracellular space; cytoplasm; extracellular regionMolecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activityBiological Process: cell death; negative regulation of myelination; negative regulation of axon regeneration; synapse organization and biogenesis; response to wounding; regulation of synapse organization and biogenesis; keratinocyte proliferation; proteolysis; neurite morphogenesis; memory |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q61955 |
| NCBI GenInfo Identifier: | 6679487 |
| NCBI Gene ID: | 259277 |
| NCBI Accession: | NP_032966.1 |
| UniProt Secondary Accession: | Q61955,Q8K5D7 |
| UniProt Related Accession: | Q61955 |
| Molecular Weight: | 55.7kDa |
| NCBI Full Name: | kallikrein-8 |
| NCBI Synonym Full Names: | kallikrein related-peptidase 8 |
| NCBI Official Symbol: | Klk8�� |
| NCBI Official Synonym Symbols: | BSP1; Nrpn; Prss19�� |
| NCBI Protein Information: | kallikrein-8; NP; mK8; neuropsin; kallikrein 8; serine protease 19; Brain Serine protease 1; protease, serine, 19 (neuropsin) |
| UniProt Protein Name: | Kallikrein-8 |
| UniProt Synonym Protein Names: | Neuropsin; NP; Serine protease 19 |
| Protein Family: | Kallikrein |
| UniProt Gene Name: | Klk8�� |
| UniProt Entry Name: | KLK8_MOUSE |
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