Description
Mouse MAPK8 Recombinant Protein (N-His)
Mouse MAPK8 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Gln384, with an N-terminal His tag. Predicted molecular weight: 46.52 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Mitogen-activated protein kinase 8 is a ~44 kDa protein. Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. For research use only.
Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins.
| Product Name: | Mouse MAPK8 Recombinant Protein (N-His) |
| SKU: | GXRP12853 |
| Size: | 50 µg, 100 µg, 1 mg |
| Synonyms: | EC:2.7.11.24, Jnk1, MAP kinase 8, MAPK 8, Mapk8, Mitogen-activated protein kinase 8, Prkm8, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Gln384 |
| Calculated MW: | 46.52 kDa |
| UniProt: | Q91Y86 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
