Description
Mouse Npsa4 Recombinant Protein (N-His)
Mouse Npsa4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Pro194, with an N-terminal His tag. Predicted molecular weight: 23.49 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Neuronal PAS domain-containing protein 4 is a ~87 kDa protein. Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. For research use only.
Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience. In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons. In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits.
| Product Name: | Mouse Npsa4 Recombinant Protein (N-His) |
| SKU: | GXRP10500 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | BHLHE79, Class E basic helix-loop-helix protein 79, HLH-PAS transcription factor NXF, NPAS4, NXF, Neuronal PAS domain-containing protein 4, Neuronal PAS4, PAS domain-containing protein 10, PASD10, bHLHe79 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Pro194 |
| Calculated MW: | 23.49 kDa |
| UniProt: | Q8BGD7 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
