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Mouse NUMB Recombinant Protein (N-His)
Key Features

Mouse NUMB Recombinant Protein (N-His) (GXRP12517)

SKU GXRP12517
Product Type Recombinant Protein
Species Mouse
Expression System E. coli
Tag N-His
$458 - $2,412

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Description

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Mouse NUMB Recombinant Protein (N-His)

Mouse NUMB Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Val16-Ala200, with an N-terminal His tag. Predicted molecular weight: 23.25 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Protein numb homolog is a ~70 kDa protein. Regulates clathrin-mediated receptor endocytosis. For research use only.

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity.

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