Description
Mouse PTPN6 Recombinant Protein (N-His)
Mouse PTPN6 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Phe244-Phe515, with an N-terminal His tag. Predicted molecular weight: 33.56 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) is a ~67 kDa protein. Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis. For research use only.
Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities. When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events. Modulates the signaling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling.
| Product Name: | Mouse PTPN6 Recombinant Protein (N-His) |
| SKU: | GXRP08698 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | Tyrosine-protein phosphatase non-receptor type 6, EC:3.1.3.48, 70Z-SHP, Hematopoietic cell protein-tyrosine phosphatase, PTPTY-42, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1, SHP-1, Ptpn6 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Phe244-Phe515 |
| Calculated MW: | 33.56 kDa |
| UniProt: | P29351 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
