Mouse S100A1 Recombinant Protein (RPPB4545)
- SKU:
- RPPB4545
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P56565
Description
| Product Name: | Mouse S100A1 Recombinant Protein |
| Product Code: | RPPB4545 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | S100A1 |
| Synonyms: | Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100a1, S100, S100a, AI266795. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | S100A1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSELESAME TLINVFHAHS GKEGDKYKLS KKELKDLLQT ELSGFLDVQK DADAVDKVMK ELDENGDGEV DFKEYVVLVA ALTVACNNFF WETS |
S100A1 is a member of the S100 family of calcium binding proteins with EF-hand type Ca+2 binding motive. S100A1 (Calcium Binding Protein A1) is involved in the activation of sarcoplasmatic calcium release and the regulation of intermediate filament polymerization. S100A1 may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of S100A1 has been implicated in cardiomyopathies.S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. There are at least 13 members in the S100 gene family, which are located as a cluster on chromosome 1q21.
S100A1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 114 amino acids (1-94 a.a) and having a molecular mass of 12.6kDa (molecular weight on SDS-PAGE will appear higher).S100A1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Probably acts as a Ca2+ signal transducer. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. |
| UniProt Code: | P56565 |
| NCBI GenInfo Identifier: | 6755386 |
| NCBI Gene ID: | 20193 |
| NCBI Accession: | NP_035439.1 |
| UniProt Secondary Accession: | P56565,O88949, |
| UniProt Related Accession: | P56565 |
| Molecular Weight: | 10,505 Da |
| NCBI Full Name: | protein S100-A1 |
| NCBI Synonym Full Names: | S100 calcium binding protein A1 |
| NCBI Official Symbol: | S100a1�� |
| NCBI Official Synonym Symbols: | S100; S100a; AI266795�� |
| NCBI Protein Information: | protein S100-A1 |
| UniProt Protein Name: | Protein S100-A1 |
| UniProt Synonym Protein Names: | S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1 |
| UniProt Gene Name: | S100a1�� |
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