Description
Mouse SAMHD1 Recombinant Protein (N-His)
Mouse SAMHD1 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Asp145-Phe658, with an N-terminal His tag. Predicted molecular weight: 62.08 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 is a ~75 kDa protein. Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. For research use only.
Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. Phosphorylation at Thr-634 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks.
| Product Name: | Mouse SAMHD1 Recombinant Protein (N-His) |
| SKU: | GXRP13409 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, EC:3.1.5.-, Interferon-gamma-inducible protein Mg11, Mg21, SAM domain and HD domain-containing protein 1, Samhd1, dNTPase, mSAMHD1 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Asp145-Phe658 |
| Calculated MW: | 62.08 kDa |
| UniProt: | Q60710 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
