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Mouse TREML4 Recombinant Protein (N-His)
Key Features

Mouse TREML4 Recombinant Protein (N-His) (GXRP12061)

SKU GXRP12061
Product Type Recombinant Protein
Species Mouse
Expression System E. coli
Tag N-His
$458 - $2,412

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Description

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Mouse TREML4 Recombinant Protein (N-His)

Mouse TREML4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser29-Pro138, with an N-terminal His tag. Predicted molecular weight: 14.94 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Trem-like transcript 4 protein is a ~29 kDa protein. Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. For research use only.

Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs).

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