Background: | Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A. |
Synonyms: | Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2 |
UniProt Protein Function: | MRGPRX2: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 11p15.1Cellular Component: integral to membrane; integral to plasma membraneMolecular Function: G-protein coupled receptor activity; neuropeptide bindingBiological Process: mast cell activation; mast cell degranulation; positive regulation of cytokinesis |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q96LB1 |
NCBI GenInfo Identifier: | 50401127 |
NCBI Gene ID: | 117194 |
NCBI Accession: | Q96LB1.1 |
UniProt Secondary Accession: | Q96LB1,Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4 Q4QXX6, Q4QXX7, B5B0C7 |
UniProt Related Accession: | Q96LB1 |
Molecular Weight: | 37,099 Da |
NCBI Full Name: | Mas-related G-protein coupled receptor member X2 |
NCBI Synonym Full Names: | MAS related GPR family member X2 |
NCBI Official Symbol: | MRGPRX2Â Â |
NCBI Official Synonym Symbols: | MGRG3; MRGX2Â Â |
NCBI Protein Information: | mas-related G-protein coupled receptor member X2 |
UniProt Protein Name: | Mas-related G-protein coupled receptor member X2 |
UniProt Synonym Protein Names: | |
Protein Family: | Mas-related G-protein coupled receptor |
UniProt Gene Name: | MRGPRX2Â Â |
UniProt Entry Name: | MRGX2_HUMAN |