UniProt Protein Function: | MSL3L1: May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factorChromosomal Location of Human Ortholog: Xp22.3Cellular Component: NuA4 histone acetyltransferase complex; nucleoplasmMolecular Function: DNA binding; methylated histone residue bindingBiological Process: chromatin remodeling; chromatin silencing; histone deacetylation |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010] |
UniProt Code: | Q8N5Y2 |
NCBI GenInfo Identifier: | 32171482 |
NCBI Gene ID: | 10943 |
NCBI Accession: | Q8N5Y2.1 |
UniProt Secondary Accession: | Q8N5Y2,Q9UG70, Q9Y5Z8, A6NCU2, A6NHW8, A8K165, B4DUV8 B7Z227 |
UniProt Related Accession: | Q8N5Y2 |
Molecular Weight: | 42,725 Da |
NCBI Full Name: | Male-specific lethal 3 homolog |
NCBI Synonym Full Names: | male-specific lethal 3 homolog (Drosophila) |
NCBI Official Symbol: | MSL3Â Â |
NCBI Official Synonym Symbols: | MSL3L1Â Â |
NCBI Protein Information: | male-specific lethal 3 homolog |
UniProt Protein Name: | Male-specific lethal 3 homolog |
UniProt Synonym Protein Names: | Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1; MSL3-like 1 |
Protein Family: | Male-specific lethal |
UniProt Gene Name: | MSL3Â Â |
UniProt Entry Name: | MS3L1_HUMAN |