Anti-MTA2 Antibody (CAB10980)

Antibody Name:	Anti-MTA2 Antibody
Antibody SKU:	CAB10980
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human MTA2

Application:	WB IHC
Recommended Dilution:	WB 1:200 - 1:1000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse
Positive Samples:

Immunogen:	A synthetic peptide of human MTA2
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	9219
Uniprot:	O94776
Cellular Location:	Nucleus
Calculated MW:	55kDa/75kDa
Observed MW:	Refer to Figures

Synonyms:

MTA2, MTA1L1, PID

Background:

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

UniProt Protein Function:	MTA2: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
UniProt Protein Details:	Protein type:Transcription factor; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Deacetylase Chromosomal Location of Human Ortholog: 11q12-q13.1 Cellular Component: nucleoplasm; transcription factor complex; protein complex; membrane; histone deacetylase complex; nuclear chromatin; NuRD complex Molecular Function:protein binding; nucleosomal DNA binding; zinc ion binding; histone deacetylase activity; transcription factor activity Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; ATP-dependent chromatin remodeling; DNA methylation; positive regulation of transcription from RNA polymerase II promoter; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter
NCBI Summary:	This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
UniProt Code:	O94776
NCBI GenInfo Identifier:	29840793
NCBI Gene ID:	9219
NCBI Accession:	O94776.1
UniProt Related Accession:	O94776
Molecular Weight:	Observed Molecular Weight: (Observed)75kD.Predicted Molecular Weight: (Calculated)75kDa.
NCBI Full Name:	Metastasis-associated protein MTA2
NCBI Synonym Full Names:	metastasis associated 1 family member 2
NCBI Official Symbol:	MTA2
NCBI Official Synonym Symbols:	PID; MTA1L1
NCBI Protein Information:	metastasis-associated protein MTA2
UniProt Protein Name:	Metastasis-associated protein MTA2
UniProt Synonym Protein Names:	Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex
Protein Family:	Metastasis-associated protein
UniProt Gene Name:	MTA2
UniProt Entry Name:	MTA2_HUMAN

	Immunohistochemistry of paraffin-embedded human tonsil using MTA2 Antibody (CAB10980) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human lung cancer using MTA2 Antibody (CAB10980) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human gastric cancer using MTA2 Antibody (CAB10980) at dilution of 1:100 (40x lens).

Antibodies

Anti-MTA2 Antibody (CAB2243)[KO Validated]

Anti-MTA2 [KO Validated] Antibody (CAB4624)

MTA2 Antibody (PACO10632)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)