| UniProt Protein Function: | MYD88: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1 and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Ubiquitous. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 3p22 Cellular Component: plasma membrane; endosome membrane; cytosol Molecular Function:identical protein binding; protein binding; death receptor binding Biological Process: positive regulation of interleukin-17 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of interleukin-23 production; positive regulation of interleukin-6 production; signal transduction; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; defense response to Gram-positive bacterium; cell surface receptor linked signal transduction; regulation of inflammatory response; positive regulation of interferon type I production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway; negative regulation of apoptosis Disease: Macroglobulinemia, Waldenstrom, Susceptibility To, 1; Myd88 Deficiency |
| NCBI Summary: | This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q99836 |
| NCBI GenInfo Identifier: | 18202671 |
| NCBI Gene ID: | 4615 |
| NCBI Accession: | Q99836.1 |
| UniProt Secondary Accession: | Q99836,P78397, Q53XS7, B4DKH8, B4DKU4, B4DQ60, B4DQ72 J3KPU4, J3KQ87, J3KQJ6, |
| UniProt Related Accession: | Q99836 |
| Molecular Weight: | 34,097 Da |
| NCBI Full Name: | Myeloid differentiation primary response protein MyD88 |
| NCBI Synonym Full Names: | myeloid differentiation primary response 88 |
| NCBI Official Symbol: | MYD88 |
| NCBI Official Synonym Symbols: | MYD88D |
| NCBI Protein Information: | myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88) |
| UniProt Protein Name: | Myeloid differentiation primary response protein MyD88 |
| Protein Family: | Myeloid differentiation primary response protein |
| UniProt Gene Name: | MYD88 |
| UniProt Entry Name: | MYD88_HUMAN |
