Anti-Na+/K+-ATPase Antibody (CAB11683)

SKU:
CAB11683
€129 - €349

Description

Technical Manual

Anti-Na+/K+-ATPase Antibody

Product Name:Anti-Na+/K+-ATPase Antibody
Product SKU:CAB11683
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Immunogen:A synthesized peptide derived from human Na+/K+-ATPase
Sequence:

Email for sequence

Gene ID:476
Swiss Prot:P05023
Synonyms:ATP1A1; ATPase Na+/K+ transporting subunit alpha 1
Calculated MW:100kDa
Observed MW:
Reactivity:Human, Mouse, Rat
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Immunohistochemistry Immunofluorescence
Positive Samples:
Cellular Location:Cell membrane, Melanosome, Multi-pass membrane protein

Product Images

Anti-Na+/K+-ATPase Antibody

Immunohistochemistry - Na+/K+-ATPase Rabbit mAb (CAB11683)

Uniprot Information

UniProt Protein Function:ATP1A1: the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane; plasma membrane; protein complex; sarcolemma; sodium:potassium-exchanging ATPase complex

Molecular Function:ATP binding; chaperone binding; potassium ion binding; protein binding; sodium ion binding; sodium:potassium-exchanging ATPase activity

Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import; regulation of sodium ion transport

NCBI Summary:The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Code:P05023
NCBI GenInfo Identifier:114374
NCBI Gene ID:476
NCBI Accession:P05023.1
UniProt Secondary Accession:P05023,Q16689, Q6LDM4, Q9UCN1, Q9UJ20, Q9UJ21, B2RBR6 B7Z2T5, B7Z3U6, F5H3A1,
UniProt Related Accession:P05023
Molecular Weight:113kDa
NCBI Full Name:Sodium/potassium-transporting ATPase subunit alpha-1
NCBI Synonym Full Names:ATPase Na+/K+ transporting subunit alpha 1
NCBI Official Symbol:ATP1A1
NCBI Protein Information:sodium/potassium-transporting ATPase subunit alpha-1
UniProt Protein Name:Sodium/potassium-transporting ATPase subunit alpha-1
UniProt Synonym Protein Names:Sodium pump subunit alpha-1
Protein Family:Sodium/potassium-transporting ATPase
UniProt Gene Name:ATP1A1
View AllClose

Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Signal Transduction
View AllClose