UniProt Protein Function: |
NOX1: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: |
Protein type:Channel, misc.; EC 1.-.-.-; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of Human Ortholog: Xq22
Cellular Component: early endosome; integral to membrane; cell junction; NADPH oxidase complex
Molecular Function:protein binding; metal ion binding; superoxide-generating NADPH oxidase activity; Rac GTPase binding; NADP binding; voltage-gated proton channel activity
Biological Process: respiratory burst; intracellular pH elevation; cell migration; extracellular matrix organization and biogenesis; positive regulation of smooth muscle cell proliferation; superoxide metabolic process; positive regulation of JNK cascade; signal transduction; regulation of systemic arterial blood pressure by renin-angiotensin; NADP metabolic process; proton transport; regulation of blood pressure; positive regulation of cell proliferation; hydrogen peroxide metabolic process; angiogenesis; positive regulation of integrin biosynthetic process; inflammatory response; superoxide release
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NCBI Summary: |
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012] |
UniProt Code: |
Q9Y5S8
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NCBI GenInfo Identifier: |
8134597 |
NCBI Gene ID: |
27035 |
NCBI Accession: |
Q9Y5S8.2 |
UniProt Secondary Accession: |
Q9Y5S8,O95691, Q2PP02, A8K836, |
UniProt Related Accession: |
Q9Y5S8 |
Molecular Weight: |
58,972 Da |
NCBI Full Name: |
NADPH oxidase 1 |
NCBI Synonym Full Names: |
NADPH oxidase 1 |
NCBI Official Symbol: |
NOX1 |
NCBI Official Synonym Symbols: |
MOX1; NOH1; NOH-1; GP91-2 |
NCBI Protein Information: |
NADPH oxidase 1; mitogenic oxidase 1; NADPH oxidase homolog-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating) |
UniProt Protein Name: |
NADPH oxidase 1 |
UniProt Synonym Protein Names: |
Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1 |
Protein Family: |
NADPH oxidase |
UniProt Gene Name: |
NOX1 |
UniProt Entry Name: |
NOX1_HUMAN |