Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134 (STMA00100). Tissue: Neuroblastoma cells (SH-SY5Y). Species: Human. Fixation: 4% PFA for 15 min. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody (STMA00100) at 1:50 for overnight at 4°C with slow rocking. Secondary Antibody: AlexaFluor 488 at 1:1000 for 1 hour at RT.
Nav1.8 Antibody [S134] is a mouse recombinant monoclonal antibody directed against Nav1.8, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and AM. Reported reactivity: Human, Mouse, Rat and Monkey. Supplied as IgG2a, purified by Protein A.
Nav1.8 is a tetrodotoxin-resistant voltage-gated sodium channel encoded by the SCN10A gene and is selectively expressed in peripheral sensory neurons, particularly nociceptors. It is critical for the transmission of noxious stimuli and contributes to the upstroke of action potentials in pain pathways. Nav1.8 is implicated in inflammatory and neuropathic pain, and its selective expression outside the central nervous system makes it a promising target for analgesic development. Unlike other sodium channels, Nav1.8 remains active at lower temperatures, supporting its role in cold-induced pain. While not directly linked to central neurodegeneration, chronic pain and peripheral nerve dysfunction are increasingly recognized as contributors to cognitive decline and neuroinflammation. Targeting Nav1.8 may therefore have indirect benefits in managing neurodegenerative disease symptoms. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
Nav1.8 Antibody [S134]
Product SKU:
STMA00100
Size:
100 µg
Target:
Nav1.8
Host Species:
Mouse
Antibody Type:
Recombinant Monoclonal
Clone ID:
S134
Research Areas:
Neuroscience, Ion Channels, Sodium Channels, Voltage-Gated Sodium Channels
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, AM
Antibody Isotype:
IgG2a
Purification:
Protein A Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Monkey
Recommended Dilution:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~220kDa. No cross reactivity against other Nav channels.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 1724-1956 of rat Nav1.8
Immunogen Species:
Rat
Accession Number:
NP_058943.1
Gene ID:
1980-12-16 00:00:00
Swiss-Prot:
Q62968
Cellular Localization:
Membrane
Alternative Names:
Nav1.8, SCN10A, Scn10a, PN3, mPN3, Sns, SNS, Peripheral nerve sodium channel 3, Pn3 (gene name), Sensory neuron sodium channel, Sodium channel protein type 10 subunit alpha, Sodium channel protein type X alpha subunit, Voltage-gated sodium channel alpha subunit Nav1.8
