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Anti-Neurokinin 1 Receptor Antibody (CAB4676)

SKU:
CAB4676
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-Neurokinin 1 Receptor Antibody
Antibody SKU:CAB4676
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Neurokinin 1 Receptor
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, SH-SY5Y, Mouse brain, Rat brain, Rat spleen
Immunogen:A synthesized peptide derived from human Neurokinin 1 Receptor
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6869
Uniprot:P25103
Cellular Location:
Calculated MW:48kDa
Observed MW:50KDa
Synonyms:NK1R, NKIR, SPR, TAC1R
Background:This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
UniProt Protein Function:TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: cell surface; integral to plasma membrane; cytoplasm; dendrite; plasma membrane

Molecular Function:protein binding; substance P receptor activity; tachykinin receptor activity

Biological Process: response to nicotine; tachykinin signaling pathway; positive regulation of leukocyte migration; response to morphine; positive regulation of saliva secretion; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; behavioral response to pain; regulation of smooth muscle cell migration; positive regulation of lymphocyte proliferation; positive regulation of stress fiber formation; positive regulation of action potential; inflammatory response; response to electrical stimulus; angiotensin mediated drinking behavior; associative learning; detection of abiotic stimulus; positive regulation of synaptic transmission, cholinergic; regulation of smooth muscle cell proliferation; eating behavior; positive regulation of synaptic transmission, GABAergic; positive regulation of hormone secretion; positive regulation of ossification; positive regulation of vascular permeability; response to ethanol; long-term memory; smooth muscle contraction involved in micturition; response to heat; response to ozone; operant conditioning; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); sperm ejaculation; response to progesterone stimulus; acute inflammatory response; positive regulation of blood pressure; positive regulation of epithelial cell proliferation

NCBI Summary:This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
UniProt Code:P25103
NCBI GenInfo Identifier:128359
NCBI Gene ID:6869
NCBI Accession:P25103.1
UniProt Secondary Accession:P25103,A8K150,
UniProt Related Accession:P25103
Molecular Weight:35,713 Da
NCBI Full Name:Substance-P receptor
NCBI Synonym Full Names:tachykinin receptor 1
NCBI Official Symbol:TACR1  
NCBI Official Synonym Symbols:SPR; NK1R; NKIR; TAC1R  
NCBI Protein Information:substance-P receptor; NK-1R; NK-1 receptor; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
UniProt Protein Name:Substance-P receptor
UniProt Synonym Protein Names:NK-1 receptor; NK-1R; Tachykinin receptor 1
Protein Family:Substance-P receptor
UniProt Gene Name:TACR1  
UniProt Entry Name:NK1R_HUMAN
Anti-Neurokinin 1 Receptor Antibody (CAB4676)Western blot - Neurokinin 1 Receptor Rabbit mAb (CAB4676)

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