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Anti-NFATC2 Antibody (CAB3107)

SKU:
CAB3107
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-NFATC2 Antibody CAB3107
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-NFATC2 Antibody CAB3107
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-NFATC2 Antibody CAB3107
€139 - €419
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Description

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Antibody Name:Anti-NFATC2 Antibody
Antibody SKU:CAB3107
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human NFATC2
Application:WB IF
Recommended Dilution:WB 1:500 - 1:1000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:K562, mouse intestine
Immunogen:A synthetic peptide of human NFATC2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4773
Uniprot:Q13469
Cellular Location:Cytoplasm, Nucleus
Calculated MW:76kDa/97kDa/98kDa/99kDa/100kDa
Observed MW:130kDa
Synonyms:NFATC2, NFAT1, NFATP
Background:This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
UniProt Protein Function:NFAT1: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. It is present in a phosphorylated the cytosol of unstimulated T cells. After T-cell activation, it is dephosphorylated by calcineurin and translocates to the nucleus as a part of a transcription complex. Two splice variant isoforms have been identified.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; ribonucleoprotein complex; nucleus; cytosol; actin cytoskeleton

Molecular Function:protein binding; DNA binding; transcription factor activity

Biological Process: response to drug; B cell receptor signaling pathway; cell migration; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of B cell proliferation; cytokine production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus

NCBI Summary:This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
UniProt Code:Q13469
NCBI GenInfo Identifier:68846905
NCBI Gene ID:4773
NCBI Accession:Q13469.2
UniProt Secondary Accession:Q13469,Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2 B5B2N8, B5B2N9, B5B2P0, B5B2P2, B5B2P3,
UniProt Related Accession:Q13469
Molecular Weight:901
NCBI Full Name:Nuclear factor of activated T-cells, cytoplasmic 2
NCBI Synonym Full Names:nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NCBI Official Symbol:NFATC2  
NCBI Official Synonym Symbols:NFAT1; NFATP  
NCBI Protein Information:nuclear factor of activated T-cells, cytoplasmic 2; NF-ATc2; NFAT pre-existing subunit; T cell transcription factor NFAT1; T-cell transcription factor NFAT1; NFAT transcription complex, preexisting component; preexisting nuclear factor of activated T-cells 2; nuclear factor of activated T-cells, preexisting component
UniProt Protein Name:Nuclear factor of activated T-cells, cytoplasmic 2
UniProt Synonym Protein Names:NFAT pre-existing subunit; NF-ATp; T-cell transcription factor NFAT1
Protein Family:NFATC2-interacting protein
UniProt Gene Name:NFATC2  
UniProt Entry Name:NFAC2_HUMAN
Anti-NFATC2 Antibody (CAB3107)Western blot analysis of extracts of various cell lines, using NFATC2 antibody (CAB3107) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-NFATC2 Antibody (CAB3107)Immunofluorescence analysis of Jurkat cells using NFATC2 Rabbit pAb (CAB3107) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-NFATC2 Antibody (CAB3107)Immunofluorescence analysis of rat spleen using NFATC2 Rabbit pAb (CAB3107) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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