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Anti-NPR3 Antibody (CAB8138)

SKU:
CAB8138
Product Type:
Antibody
Applications:
WB
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 11 Anti-NPR3 Antibody CAB8138
  • Cell Biology Antibodies 11 Anti-NPR3 Antibody CAB8138
€139 - €419
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Description

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Antibody Name:NPR3 Rabbit Polyclonal Antibody
Antibody SKU:CAB8138
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 272-541 of human NPR3 (NP_001191304.1).
Application:WB IF
Recommended Dilution:WB 1:1000 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 272-541 of human NPR3 (NP_001191304.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LVAH RHGM TSGD YAFF NIEL FNSS SYGD GSWK RGDK HDFE AKQA YSSL QTVT LLRT VKPE FEKF SMEV KSSV EKQG LNME DYVN MFVE GFHD AILL YVLA LHEV LRAG YSKK DGGK IIQQ TWNR TFEG IAGQ VSID ANGD RYGD FSVI AMTD VEAG TQEV IGDY FGKE GRFE MRPN VKYP WGPL KLRI DENR IVEH TNSS PCKS SGGL EESA VTGI VVGA LLGA GLLM AFYF FRKK YRIT IERR TQQE ESNL GKHR ELRE DSIR SHFS VA
Gene ID:4883
Uniprot:P17342
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:36kDa/59kDa
Observed MW:60kDa
Synonyms:NPR3, ANP-C, ANPR-C, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC
Background:This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
NCBI Summary:This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
UniProt Code:P17342
NCBI GenInfo Identifier:27735161
NCBI Gene ID:4883
NCBI Accession:P17342.2
UniProt Secondary Accession:P17342,A2RRD1, B4DT84, E7EPG9,
UniProt Related Accession:P17342
Molecular Weight:36,656 Da
NCBI Full Name:Atrial natriuretic peptide receptor 3
NCBI Synonym Full Names:natriuretic peptide receptor 3
NCBI Official Symbol:NPR3  
NCBI Official Synonym Symbols:NPRC; ANP-C; ANPRC; NPR-C; ANPR-C; GUCY2B; C5orf23  
NCBI Protein Information:atrial natriuretic peptide receptor 3
UniProt Protein Name:Atrial natriuretic peptide receptor 3
UniProt Synonym Protein Names:Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C
Protein Family:Nitrogen permease regulator
UniProt Gene Name:NPR3  
UniProt Entry Name:ANPRC_HUMAN
Anti-NPR3 Polyclonal Antibody (CAB8138)Western blot analysis of extracts of various cell lines, using NPR3 antibody (CAB8138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
Anti-NPR3 Polyclonal Antibody (CAB8138)Immunofluorescence analysis of U2OS cells using NPR3 antibody (CAB8138) at dilution of 1:100. Blue: DAPI for nuclear staining.

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