NR1I3 Rabbit Polyclonal Antibody (CAB17066)
- SKU:
- CAB17066
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | NR1I3 Rabbit Polyclonal Antibody |
SKU: | CAB17066 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human NR1I3 (NP_001070948.1). |
Sequence: | PVQL SKEQ EELI RTLL GAHT RHMG TMFE QFVQ FRPP AHLF IHHQ PLPT LAPV LPLV THFA DINT FMVL QVIK FTKD LPVF RSLP IEDQ ISLL KGAA VEIC HIVL NTTF CLQT QNFL CGPL RYTI EDGA RVSP TVGF QVEF LELL FHFH GTLR KLQL QEPE YVLL AAMA LFSP DRPG VTQR DEID QLQE EMAL TLQS YIKG QQRR PRDR FLYA KLLG LLAE LRSI NEAY GYQI QHIQ GLSA MMPL LQEI CS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | CAR; CAR1; MB67; NR1I3 |
Positive Sample: | Mouse liver,Rat liver |
Cellular Localization: | Cytoplasm, Nucleus, cytoskeleton. |
Calculated MW: | 40kDa |
Observed MW: | 40kDa |
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9970 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |