The TrkB Antibody (CAB12325) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific to NTRK2 and has been validated for use in various applications, including Western blot and immunohistochemistry.NTRK2, also known as TrkB, plays a crucial role in promoting neuronal survival and differentiation, as well as synaptic transmission in the brain. Dysfunction of NTRK2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
TrkB Antibody
SKU:
CAB12325
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Cell Membrane, Endosome Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
92kDa
Observed MW:
105kDa
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
4915
RRID
AB_2759175
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TrkB Rabbit pAb (CAB12325) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
