Anti-P Glycoprotein Antibody (CAB19093)

SKU:
CAB19093
€129 - €349

Description

Technical Manual

Anti-P Glycoprotein Antibody

Product Name:Anti-P Glycoprotein Antibody
Product SKU:CAB19093
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Immunogen:A synthesized peptide derived from human P Glycoprotein
Sequence:

Email for sequence

Gene ID:5243
Swiss Prot:P08183
Synonyms:ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1; P Glycoprotein; ABCB1
Calculated MW:180kDa
Observed MW:130-180kDa
Reactivity:Human, Mouse, Rat
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry
Positive Samples:HepG2, SH-SY5Y, Mouse liver, Rat liver
Cellular Location:

Product Images

Anti-P Glycoprotein Antibody (CAB19093)

Western blot - P Glycoprotein Rabbit mAb (CAB19093)

Uniprot Information

UniProt Protein Function:ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.
UniProt Protein Details:

Protein type:Hydrolase; Cell adhesion; Transporter; Membrane protein, integral; Membrane protein, multi-pass; EC 3.6.3.44; Transporter, ABC family

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane

Molecular Function:protein binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity; xenobiotic-transporting ATPase activity; ATP binding

Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; G2/M transition of mitotic cell cycle; transmembrane transport

Disease: Colchicine Resistance; Inflammatory Bowel Disease 13

NCBI Summary:The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
UniProt Code:P08183
NCBI GenInfo Identifier:238054374
NCBI Gene ID:5243
NCBI Accession:P08183.3
UniProt Secondary Accession:P08183,Q12755, Q14812, A8K294, B5AK60,
UniProt Related Accession:P08183
Molecular Weight:134,032 Da
NCBI Full Name:Multidrug resistance protein 1
NCBI Synonym Full Names:ATP-binding cassette, sub-family B (MDR/TAP), member 1
NCBI Official Symbol:ABCB1
NCBI Official Synonym Symbols:CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
NCBI Protein Information:multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance
UniProt Protein Name:Multidrug resistance protein 1
UniProt Synonym Protein Names:ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243
Protein Family:ABC transporter B family
UniProt Gene Name:ABCB1
UniProt Entry Name:MDR1_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
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