The PANK2 Antibody (CAB18502) is a high-quality antibody developed for reliable detection and analysis of target proteins. This rabbit polyclonal antibody has high reactivity with human samples and has been validated for use in Western blot applications.PANK2 plays a crucial role in cellular metabolism, specifically in the biosynthesis of CoA, a coenzyme essential for numerous metabolic pathways. Dysregulation of PANK2 has been linked to neurodegenerative disorders such as pantothenate kinase-associated neurodegeneration (PKAN).
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse samples.
Product Name:
PANK2 Antibody
SKU:
CAB18502
Size:
20μL, 100μL
Reactivity:
Mouse
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
Purification Method
Affinity purification
Gene ID
80025
RRID
AB_2862266
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using PANK2 Rabbit pAb (CAB18502) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
