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Anti-PCM1 Antibody (CAB5696)

SKU:
CAB5696
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 9 Anti-PCM1 Antibody CAB5696
  • Cell Biology Antibodies 9 Anti-PCM1 Antibody CAB5696
  • Cell Biology Antibodies 9 Anti-PCM1 Antibody CAB5696
€139 - €419
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Description

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Antibody Name:Anti-PCM1 Antibody
Antibody SKU:CAB5696
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_006188.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SW480, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_006188.3).
Purification Method:Affinity purification
Storage Buffer:Store at 4?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:MATG GGPF EDGM NDQD LPNW SNEN VDDR LNNM DWGA QQKK ANRS SEKN KKKF GVES DKRV TNDI SPES SPGV GRRR TKTP HTFP HSRY MSQM SVPE QAEL EKLK QRIN FSDL DQRS IGSD SQGR ATAA NNKR QLSE NRKP FNFL PMQI NTNK SKDA STSP PNRE TIGS AQCK ELFA SALS NDLL QNCQ VSEE DGRG EPAM ESSQ IVSR LVQI RDYI TKAS SMRE DLVE KNER SANV ERLT HLID HLKE QEKS YMKF LKKI
Gene ID:5108
Uniprot:Q15154
Cellular Location:Cytoplasm, Cytoplasmic granule, centriolar satellite, centrosome, cilium basal body, cytoskeleton, microtubule organizing center
Calculated MW:59kDa/222kDa/228kDa
Observed MW:300kDa
Synonyms:PCM1, PTC4, RET/PCM-1
Background:The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Code:Q15154
NCBI GenInfo Identifier:134142826
NCBI Gene ID:5108
NCBI Accession:NP_006188.3
UniProt Secondary Accession:Q15154,Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2,
UniProt Related Accession:Q15154
Molecular Weight:59,199 Da
NCBI Full Name:pericentriolar material 1 protein
NCBI Synonym Full Names:pericentriolar material 1
NCBI Official Symbol:PCM1  
NCBI Official Synonym Symbols:PTC4  
NCBI Protein Information:pericentriolar material 1 protein; PCM-1; hPCM-1; pericentriolar material 1, PCM1
UniProt Protein Name:Pericentriolar material 1 protein
Protein Family:Pericentriolar material 1 protein
UniProt Gene Name:PCM1  
UniProt Entry Name:PCM1_HUMAN
Anti-PCM1 Antibody (CAB5696)Western blot analysis of extracts of various cell lines, using PCM1 antibody (CAB5696) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-PCM1 Antibody (CAB5696)Immunohistochemistry of paraffin-embedded mouse liver using PCM1 Antibody (CAB5696) at dilution of 1:100 (40x lens).
Anti-PCM1 Antibody (CAB5696)Immunohistochemistry of paraffin-embedded human liver cancer using PCM1 Antibody (CAB5696) at dilution of 1:100 (40x lens).

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