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Key Features

Anti-PDI Antibody

Datasheet MSDS
SKU STPA00010
Antibody Type Polyclonal
Applications WB
Applications IHC
Applications ICC/IF
Applications IP
Reactivity Human
Reactivity Mouse
Reactivity Rat
Reactivity Bovine
Reactivity Dog
Reactivity Hamster
Reactivity Guinea Pig (Cavia porcellus)
Reactivity Sheep
Reactivity Pig
Reactivity African clawed frog (Xenopus laevis)
Reactivity Mollusk
Reactivity Mussel (Perna viridis)
Host Species Rabbit
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Description

PDI Antibody

PDI Antibody is a rabbit polyclonal antibody directed against PDI, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and IP. Reported reactivity: Human, Mouse, Rat, Bovine, Dog, Hamster, Guinea Pig (Cavia porcellus), Sheep, Pig, African clawed frog (Xenopus laevis), Mollusk and Mussel (Perna viridis). Purified by Protein A.

Protein disulfide isomerase (PDI) is a thiol-disulfide oxidoreductase that facilitates protein folding and quality control in the endoplasmic reticulum (ER). In neurons, PDI plays a protective role by preventing the accumulation of misfolded proteins and maintaining redox homeostasis. Under conditions of ER stress—common in neurodegenerative diseases—PDI expression is upregulated as part of the unfolded protein response (UPR). However, excessive or dysfunctional PDI activity has been linked to protein aggregation and oxidative damage in Alzheimer’s, ALS, and Parkinson’s disease. PDI’s dual role in neuroprotection and pathology makes it a compelling target for therapeutic strategies aimed at modulating ER stress and proteostasis in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µl. For research use only; not for diagnostic or therapeutic procedures.

Product Name:PDI Antibody
Product SKU:STPA00010
Size:100 µl
Target:PDI
Host Species:Rabbit
Antibody Type:Polyclonal
Research Areas:Cell Signaling, Protein Trafficking, Chaperone Proteins, Tags and Cell Markers, Organelle Markers
Buffer:PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, IHC, ICC/IF, IP
Purification:Protein A purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat, Bovine, Dog, Hamster, Guinea Pig (Cavia porcellus), Sheep, Pig, African clawed frog (Xenopus laevis), Mollusk, Mussel (Perna viridis)
Recommended Dilution:WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:Detects ~58kDa.
Guarantee:12 months from date of dispatch
Immunogen:AA499-509 of Rat PDI
Immunogen Species:Rat
Swiss-Prot:P04785
Cellular Localization:Endoplasmic Reticulum | Endoplasmic Reticulum Lumen
Alternative Names:Thioredoxin domain containing 5, ERP46, UNQ364, MGC3178, FLJ21353, FLJ90810, thioredoxin related protein, endothelial protein disulphide isomeras
References:1. NA K.S. et al. (2007) Mol Cells. 24(2): 261-7. 2. Mayer M., Kies U., Kammermeier R., and Buchner J. (2000) J Biol Chem. 275(38): 29421-5. 3. Delom F., Mallet B., Carayon P., and Lejeune P.J. (2001) J Biol Chem 276(24): 21337-42. 4. Schultz-Norton J.R., McDonald W.H., Yates J.R. and Nardulli A.M. (2006) Mol Endocrinol 20(9): 1982-95. 5. Turano C., Coppari S. Altieri F. and Ferraro (2002) J Cell Physiol 193: 154-163. 6. Janiszewski M. (2005) J. Biol Chem. 280(49): 40813- 40819. 7. Yoshimori T., et al. (1990) J Biol Chem. 265(26): 15984-90.
Note:For research use only.

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