Description

PE/Cyanine5 Anti-Mouse CD54 Antibody [YN1/1.7.4]

The PE-Cyanine5 Anti-Mouse CD54 Antibody (YN1/1.7.4) offered on www.assaygenie.com is a powerful tool for researchers studying immune responses in mice. This antibody, specifically designed to target CD54, a cell surface adhesion molecule involved in immune cell interactions, provides high reactivity and specificity for mouse samples. Validated for applications such as flow cytometry, immunofluorescence, and immunohistochemistry, this antibody allows for precise detection and analysis of CD54 expression in various cell types within the immune system.CD54, also known as intercellular adhesion molecule-1 (ICAM-1), plays a crucial role in immune cell communication and recruitment during the inflammatory response.

Understanding the expression and function of CD54 is essential in unraveling the complex mechanisms underlying immune surveillance, inflammation, and host defense. Researchers interested in investigating immune-related processes, such as immune cell activation, migration, and adhesion, will find this antibody invaluable in their studies.By utilizing the PE-Cyanine5 Anti-Mouse CD54 Antibody (YN1/1.7.4), researchers can gain insights into the intricate interplay of immune cells and their microenvironment, paving the way for advancements in immunology, inflammation research, and therapeutic development targeting immune-related disorders and diseases.

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Product Title:	PE/Cyanine5 Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:	AGEL3137
Size:	50 Tests, 100 Tests, 200 Tests
Clone No:	YN1/1.7.4
Synonyms:	Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2b, κ
Isotype Control:	PE/Cyanine5 Rat IgG2b, κ Isotype Control[LTF-2]
Form:	Liquid
Conjugation:	PE/Cyanine 5
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P13597
Gene ID:	15894
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

PE/Cyanine5 Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL3137)

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