Description

PerCP/Cyanine5.5 Anti-Human CD163 Antibody [GHI/61]

The PerCP-Cyanine5.5 Anti-Human CD163 Antibody (GHI-61) offered by AssayGenie is a valuable tool for researchers investigating CD163, a cell surface marker primarily expressed on monocytes and macrophages. This monoclonal antibody, optimized for flow cytometry studies, allows for specific detection and quantification of CD163-positive cells in human samples.CD163 is a key scavenger receptor involved in the clearance of hemoglobin-haptoglobin complexes and has been implicated in various immune and inflammatory processes. Its expression is often upregulated in conditions such as inflammation, infection, and cancer, making it a promising target for immuno-oncology research and studies on immune cell function.

Validated for use in flow cytometry, the PerCP-Cyanine5.5 Anti-Human CD163 Antibody (GHI-61) provides researchers with a reliable tool to analyze CD163 expression levels in different cell populations, aiding in the understanding of its role in disease pathogenesis and immune response modulation. With its high specificity and sensitivity, this antibody is a valuable asset for studies in immunology, oncology, and other related fields.

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Product Title:	PerCP/Cyanine5.5 Anti-Human CD163 Antibody [GHI/61]
SKU:	AGEL3401
Size:	20 Tests, 100 Tests, 200 Tests
Clone No:	GHI/61
Synonyms:	GHI/61; M130; RM3/1; p155; Hemoglobin/Haptoglobin Complex Receptor; macrophage-associated antigen; ED2(rat);
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	PerCP/Cyanine 5.5
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	Q86VB7
Gene ID:	9332
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.

PerCP/Cyanine5.5 Anti-Human CD163 Antibody [GHI/61] (AGEL3401)

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Description