Description

PerCP/Cyanine5.5 Anti-Human CD49d Antibody [HP1/2]

The PerCP-Cyanine5.5 Anti-Human CD49d Antibody (HP1/2) is a powerful tool for researchers studying immune cell populations and cell adhesion molecules within the human body. This antibody, optimized for flow cytometry applications, specifically targets CD49d, a key integrin involved in cell adhesion and migration processes.CD49d, also known as alpha-4 integrin, is a crucial protein in the immune system, facilitating the binding of leukocytes to endothelial cells during inflammation and immune responses. The PerCP-Cyanine5.5 Anti-Human CD49d Antibody (HP1/2) offers high specificity and sensitivity in detecting CD49d expression on various cell types, providing valuable insights into immune cell interactions and inflammatory processes.

By using this antibody in flow cytometry experiments, researchers can analyze the expression levels of CD49d on different cell populations, investigate its role in immune cell trafficking, and explore its potential as a therapeutic target in conditions such as inflammatory disorders and autoimmune diseases. The PerCP-Cyanine5.5 Anti-Human CD49d Antibody (HP1/2) is a reliable tool for advancing research in immunology, inflammation, and related fields.

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Product Title:	PerCP/Cyanine5.5 Anti-Human CD49d Antibody [HP1/2]
SKU:	AGEL3483
Size:	20 Tests, 100 Tests, 200 Tests
Clone No:	HP1/2
Synonyms:	VLA-4 α chain; α4 integrin; Integrin α4 chain; ITGA4;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG2a, κ
Isotype Control:	PerCP/Cyanine5.5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:	Liquid
Conjugation:	PerCP/Cyanine 5.5
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P13612
Gene ID:	3676
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.

PerCP/Cyanine5.5 Anti-Human CD49d Antibody [HP1/2] (AGEL3483)

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