Description

PerCP/Cyanine5.5 Anti-Human CD61 Antibody [VI-PL2]

The PerCP-Cyanine5.5 Anti-Human CD61 Antibody (VI-PL2) is a vital tool for researchers studying the CD61 protein, which is a key marker for platelets and megakaryocytes. This monoclonal antibody is specifically designed for use in flow cytometry applications, allowing for precise detection and characterization of CD61-expressing cells in human samples.CD61, also known as integrin beta 3, plays a crucial role in platelet aggregation and adhesion, making it essential for normal hemostasis and thrombosis. Its expression pattern and function in various cell types, including platelets and megakaryocytes, highlight its importance in vascular biology and clot formation processes.

The PerCP-Cyanine5.5 Anti-Human CD61 Antibody (VI-PL2) offers high sensitivity and specificity in detecting CD61, enabling researchers to accurately profile and quantify CD61-positive cells in complex biological samples. This antibody is an invaluable tool for investigations in hematology, vascular biology, and thrombosis research, providing a deeper understanding of CD61's role in platelet function and cardiovascular health.

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Product Title:	PerCP/Cyanine5.5 Anti-Human CD61 Antibody [VI-PL2]
SKU:	AGEL3166
Size:	20 Tests, 100 Tests, 200 Tests
Clone No:	VI-PL2
Synonyms:	GP3A;GPIIIa;ITGB3;Integrin beta-3;
Host Species:	Mouse
Reactivity:	Human
Application:	FCM

Isotype:	Mouse IgG1, κ
Isotype Control:	PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:	Liquid
Conjugation:	PerCP/Cyanine 5.5
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:

Swissprot:	P05106
Gene ID:	3690
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin αV (CD51) to form αV/β3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.

PerCP/Cyanine5.5 Anti-Human CD61 Antibody [VI-PL2] (AGEL3166)

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Description