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Phospho-α-Synuclein-Y133 Polyclonal Antibody (CABP0451)

SKU:
CABP0451
Product Type:
Antibody
Applications:
WB
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 16 Anti-Phospho-Alpha-synuclein-Y133 Antibody CABP0451
  • Cell Biology Antibodies 16 Anti-Phospho-Alpha-synuclein-Y133 Antibody CABP0451
€129
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-α-Synuclein-Y133 Polyclonal Antibody
SKU:CABP0451
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A phospho specific peptide corresponding to residues surrounding Y133 of human alpha-Synuclein
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:PD1; NACP; PARK1; PARK4; Phospho-α-Synuclein-Y133
Positive Sample:Jurkat,NIH/3T3
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, cytosol, synapse.
Calculated MW:14kDa
Observed MW:20kDa

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Purification Method:Affinity purification
Gene ID:6622
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Phospho-α-Synuclein-Y133 pAb (CABP0451) at 1:1000 dilution.Jurkat and NIH/3T3 cells were treated by Pervanadate (1 mM) at 37℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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