Phospho-c-Myc-T58 Rabbit Monoclonal Antibody (CABP0990)
- SKU:
- CABP0990
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Product Name: | Phospho-c-Myc-T58 Rabbit Monoclonal Antibody |
| SKU: | CABP0990 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | A synthetic phosphorylated peptide around T58 of human c-Myc (P01106). |
| Sequence: | LPTP P |
| Tested Applications: | WB ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 |
| Synonyms: | MRTL; MYCC; c-Myc; bHLHe39; Phospho-c-Myc-T58 |
| Positive Sample: | HeLa |
| Conjugate: | Unconjugated |
| Cellular Localization: | Nucleus, Nucleolus, Nucleoplasm. |
| Calculated MW: | 51kDa |
| Observed MW: | 57kDa |
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.
| Purification Method: | Affinity purification |
| Gene ID: | 4609 |
| Clone Number: | ARC1534 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
 | Western blot analysis of extracts of HeLa cells, using Phospho-c-Myc-T58 Rabbit mAb (CABP0990) at 1:1000 dilution.Hela cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s. |
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