Anti-phospho-LATS1-T1079/LATS2-T1041 Antibody (CABP0912)

SKU:
CABP0912
€99 - €319

Description

Technical Manual

Anti-phospho-LATS1-T1079/LATS2-T1041 Antibody

Product Name:Anti-phospho-LATS1-T1079/LATS2-T1041 Antibody
Product SKU:CABP0912
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Immunogen:A phospho specific peptide corresponding to residues surrounding T1079 of human LATS1.
Sequence:

Email for sequence

Gene ID:9113/26524
Swiss Prot:O95835/Q9NRM7
Synonyms:LATS1; WARTS; wts
Calculated MW:76kDa/126kDa
Observed MW:140KDa
Reactivity:Human
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:HeLa
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center

Product Images

Anti-phospho-LATS1-T1079/LATS2-T1041 Antibody (CABP0912)

Western blot - phospho-LATS1-T1079/LATS2-T1041 Rabbit pAb (CABP0912)
View AllClose

Additional Information

Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
View AllClose